根据LIN28A表达情况分析胃癌患者的临床病理特征
Clinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A.
作者信息
Park Chan Hyuk, Lee Jung Hwa, Lee Na Keum, Lee Yong Chan, Lee Sang Kil
机构信息
Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2016 Sep 15;10(5):714-8. doi: 10.5009/gnl15283.
BACKGROUND/AIMS: Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored. We sought to evaluate clinicopathological characteristics according to the expression of LIN28A in numerous gastric cancer tissue samples.
METHODS
LIN28A expression was evaluated by immunohistochemical (IHC) analysis of a tissue microarray comprising 288 gastric cancer tissues and 288 adjacent normal tissues. Clinicopathological characteristics, including overall survival, were compared according to LIN28A expression.
RESULTS
The IHC staining score was lower for the cancer tissues than the normal tissues (p<0.001). However, no significant differences were observed in the clinicopathological characteristics between the low and high LIN28A expression groups. In addition, the 5-year overall survival rate did not differ between the two groups: 75.3% (95% confidence interval [CI], 69.3% to 81.7%) versus 71.6% (95% CI, 63.3% to 80.9%) for low versus high expression, respectively.
CONCLUSIONS
The expression of LIN28A did not appear to play a distinct role in predicting the clinicopathological characteristics of patients with gastric cancer. In addition, LIN28A expression was not an independently associated factor for overall survival in patients with gastric cancer.
背景/目的：尽管已知LIN28A可能在多种癌症的肿瘤发生中发挥作用，但LIN28A表达是否为胃癌患者预后不良的预测指标尚未得到充分研究。我们试图根据大量胃癌组织样本中LIN28A的表达情况评估临床病理特征。
方法
通过对包含288个胃癌组织和288个相邻正常组织的组织芯片进行免疫组织化学（IHC）分析来评估LIN28A表达。根据LIN28A表达情况比较包括总生存期在内的临床病理特征。
结果
癌组织的IHC染色评分低于正常组织（p<0.001）。然而，LIN28A低表达组和高表达组之间的临床病理特征未观察到显著差异。此外，两组的5年总生存率无差异：低表达组和高表达组分别为75.3%（95%置信区间[CI]，69.3%至81.7%）和71.6%（95%CI，63.3%至80.9%）。
结论
LIN28A表达在预测胃癌患者临床病理特征方面似乎未发挥明显作用。此外，LIN28A表达不是胃癌患者总生存期的独立相关因素。
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