妊娠合并胃癌的预后：一项年龄、性别和分期匹配的病例对照研究。
Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study.
作者信息
Song Min Jeong, Park Young Soo, Song Ho June, Park Se Jeong, Ahn Ji Yong, Choi Kee Don, Lee Gin Hyug, Jung Hwoon-Yong, Yook Jeong Hwan, Kim Byung Sik
机构信息
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2016 Sep 15;10(5):731-8. doi: 10.5009/gnl15323.
BACKGROUND/AIMS: Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer.
METHODS
All consecutive patients who presented to our tertiary referral hospital with pregnancy-associated gastric cancer from 1991 to 2012 were identified. Two age-, sex-, and stagematched controls for each case were also identified from the records. Clinicopathological, gynecological, and oncological outcomes were recorded. Immunohistochemical staining was performed for estrogen receptor, progesterone receptor, epidermal growth factor receptor, human epidermal growth factor receptor, and E-cadherin. Fluorescence in situ hybridization was performed for fibroblast growth factor receptor 2.
RESULTS
The median overall survival rates of the pregnancyassociated gastric cancer and control groups were 7.0 months and 15.0 months, respectively (p=0.189). Poor prognostic factors included advanced stage and tumor location in the corpus or the entire stomach but not pregnancy status or loss of E-cadherin. Pregnancy-associated gastric cancer was associated with a longer time from diagnosis to treatment (21 days vs 7 days, p=0.021). The two groups did not differ in the expression of the receptors or E-cadherin.
CONCLUSIONS
The dismal prognosis of pregnancy-associated gastric cancer may related to the tumor stage and location rather than to pregnancy itself.
背景/目的：妊娠相关胃癌是一种罕见疾病。本病例对照研究旨在确定妊娠相关胃癌的临床病理特征和预后因素。
方法
确定了1991年至2012年期间在我们的三级转诊医院就诊的所有连续妊娠相关胃癌患者。还从记录中为每个病例确定了两个年龄、性别和分期匹配的对照。记录临床病理、妇科和肿瘤学结果。对雌激素受体、孕激素受体、表皮生长因子受体、人表皮生长因子受体和E-钙黏蛋白进行免疫组织化学染色。对成纤维细胞生长因子受体2进行荧光原位杂交。
结果
妊娠相关胃癌组和对照组的中位总生存率分别为7.0个月和15.0个月（p=0.189）。不良预后因素包括晚期以及肿瘤位于胃体或全胃，但不包括妊娠状态或E-钙黏蛋白缺失。妊娠相关胃癌从诊断到治疗的时间较长（21天对7天，p=0.021）。两组在受体或E-钙黏蛋白的表达上没有差异。
结论
妊娠相关胃癌的预后不佳可能与肿瘤分期和位置有关，而不是与妊娠本身有关。
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