Department of Anaesthetics, Royal Devon and Exeter NHS Foundation Trust, Exeter EX2 5DW
Department of Anaesthetics, Royal Devon and Exeter NHS Foundation Trust, Exeter EX2 5DW.
Br J Anaesth. 2016 Apr;116(4):518-23. doi: 10.1093/bja/aev555. Epub 2016 Feb 17.
Ketamine is growing in popularity for procedural sedation in the paediatric population, yet safety concerns remain. We performed a retrospective review of practice and outcomes of paediatric ketamine sedation using the World SIVA International Sedation Task Force reporting tool.
A retrospective inspection of the dedicated emergency department electronic sedation database and subsequent note and sedation chart review was performed for all paediatric sedations throughout a 7 yr period from September 2006. All adverse events were stratified.
During the study period, procedural sedation was provided for a total of 243 children, of whom 215 were sedated with ketamine, most commonly for wound management (n=131). The median patient age was 4 yr (14 months to 15 yr), and 63.7% were male. Of the total, 76.7% were discharged home either directly (n=101) or after brief observation (n=64). One patient required subsequent general anaesthesia after a failed sedation with paradoxical agitation. Of the total, 9.8% of patients had an adverse event, the most severe risk stratification being 'minor risk'. All interventions were 'minimal risk'. There were no 'sentinel risk' outcomes.
These data support the ongoing use of ketamine for paediatric procedural sedation in the emergency department by emergency physicians. Relatively high resource requirements mean that ensuring adequate numbers of procedures may prove challenging.
氯胺酮在儿科人群中用于程序镇静的应用越来越多,但安全性问题仍然存在。我们使用世界 SIVA 国际镇静任务组报告工具对儿科氯胺酮镇静的实践和结果进行了回顾性研究。
对专门的急诊电子镇静数据库进行回顾性检查,并对 2006 年 9 月至 7 年间所有儿科镇静的病历和镇静图表进行了后续审查。所有不良事件均进行分层。
在研究期间,共有 243 名儿童接受了程序镇静,其中 215 名使用氯胺酮镇静,最常见的是用于伤口处理(n=131)。患者的中位年龄为 4 岁(14 个月至 15 岁),63.7%为男性。其中,76.7%的患者直接出院(n=101)或短暂观察后出院(n=64)。1 名患者因镇静失败出现矛盾性激惹而需要随后进行全身麻醉。在总共的患者中,9.8%的患者发生了不良事件,风险分层最严重的为“轻度风险”。所有干预措施均为“轻度风险”。没有“警戒风险”的结果。
这些数据支持急诊医师在急诊科继续使用氯胺酮进行儿科程序镇静。相对较高的资源需求意味着确保足够数量的手术可能具有挑战性。