新型激素拮抗剂产生菌——森林链霉菌ATCC 53525的基因组序列草图
Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists.
作者信息
Johnston Chad W, Li Yongchang, Magarvey Nathan A
机构信息
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada
出版信息
Genome Announc. 2016 Feb 18;4(1):e00001-16. doi: 10.1128/genomeA.00001-16.
Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a promising source for genome-guided drug discovery efforts.
森林链霉菌产生非核糖体肽，这些肽可作为人类催产素和加压素受体的拮抗剂。在此，我们展示了森林链霉菌ATCC 53525的基因组序列，并证明该生物体拥有许多额外的生物合成基因簇，可能是基因组导向药物发现研究的一个有前景的来源。
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