Tabashnik B E
J Econ Entomol. 1989 Oct;82(5):1263-9. doi: 10.1093/jee/82.5.1263.
Sequences, mixtures, rotations, and mosaics are potential strategies for using more than one pesticide to manage pest populations and for slowing the evolution of pesticide resistance. Results from theoretical models suggest that, under certain conditions, mixtures might be especially effective for resistance management. The assumptions of such models, however, are probably not widely applicable. Potential disadvantages associated with mixtures that are usually not considered in modeling studies include disruption of biological control, promotion of resistance in secondary pests, and intense selection for cross-resistance. Results from limited experimental work suggest that pesticide combinations do not consistently suppress resistance development. More thorough evaluation of tactics that seek to optimize benefits of more than one insecticide will require rigorous experiments with the particular pest and pesticide combinations. Because of the difficulty in generalizing results across systems and the potential negative effects of multiple insecticide use, emphasis on minimizing insecticide use is recommended.
序列、混合、轮用和镶嵌是使用多种杀虫剂来控制害虫种群以及减缓抗药性进化的潜在策略。理论模型的结果表明，在某些条件下，混合使用杀虫剂可能对抗性治理特别有效。然而，此类模型的假设可能并不具有广泛适用性。建模研究中通常未考虑的与混合使用杀虫剂相关的潜在缺点包括干扰生物防治、促进次要害虫产生抗性以及强烈选择交叉抗性。有限的实验工作结果表明，农药组合并不能始终抑制抗性发展。要更全面地评估旨在优化多种杀虫剂效益的策略，就需要针对特定的害虫和农药组合进行严格实验。由于难以将结果推广到不同系统，以及使用多种杀虫剂可能产生负面影响，因此建议着重尽量减少杀虫剂的使用。
