Uzunlulu Mehmet, Telci Caklili Ozge, Oguz Aytekin
Department of Internal Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Ann Nutr Metab. 2016;68(3):173-9. doi: 10.1159/000443743. Epub 2016 Feb 20.
Growing data show the association of metabolic syndrome (MetS) or its components with cancer development and cancer-related mortality. It is suggested that in MetS and cancer association, insulin resistance and insulin-like growth factor 1 system play a key role, especially adipokines secreted from visceral adipocytes, free fatty acids and aromatase activity contribute to this process. It is also reported that MetS has a link with colorectal, breast, endometrial, pancreas, primary liver and, although controversial, prostate cancer. Although every component of MetS is known to have an association with cancer development, it is still debated whether the effects of these components are additive or synergistic. On the other hand, in the association between MetS and cancer, the role of antidiabetic and antihypertensive treatments including thiazolidinedione, insulin, angiotensin receptor blockers is also suggested. The primary approach in MetS-cancer relation is to prevent risk factors. Life style changes including weight loss and a healthy diet are known to decrease cancer risk in normal population. It is postulated that an insulin-sensitizing agent, metformin, has cancer-preventing effects on diabetic patients. This review discusses the relationship between MetS and cancer from different aspects and examines this relationship in some of the cancers suggested to be linked with MetS.
越来越多的数据表明，代谢综合征（MetS）及其组分与癌症发生和癌症相关死亡率之间存在关联。有人提出，在MetS与癌症的关联中，胰岛素抵抗和胰岛素样生长因子1系统起着关键作用，尤其是内脏脂肪细胞分泌的脂肪因子、游离脂肪酸和芳香化酶活性促成了这一过程。另据报道，MetS与结直肠癌、乳腺癌、子宫内膜癌、胰腺癌、原发性肝癌有关，前列腺癌虽存在争议但也与之有关。虽然已知MetS的每个组分都与癌症发生有关，但这些组分的作用是相加的还是协同的仍存在争议。另一方面，在MetS与癌症的关联中，还提出了包括噻唑烷二酮、胰岛素、血管紧张素受体阻滞剂在内的抗糖尿病和抗高血压治疗的作用。MetS与癌症关系的主要方法是预防危险因素。众所周知，包括体重减轻和健康饮食在内的生活方式改变可降低正常人群的癌症风险。据推测，胰岛素增敏剂二甲双胍对糖尿病患者具有防癌作用。本综述从不同方面讨论了MetS与癌症之间的关系，并在一些被认为与MetS相关的癌症中研究了这种关系。
