Hajjar Ihab, Goldstein Felicia C, Waller Edmund K, Moss Lauren D, Quyyumi Arshed
Division of General Internal Medicine and Geriatrics, Department of Medicine, Emory University, Atlanta, Georgia.
Department of Neurology, Emory University, Atlanta, Georgia.
Am J Med Sci. 2016 Feb;351(2):147-52. doi: 10.1016/j.amjms.2015.11.009.
Cognitive and cardiovascular disorders share many risk factors. Higher bone-marrow derived progenitor cells (PC) in blood are associated with lower rates of cardiovascular events but the association of PC with cognitive function is unclear. The objective of this study was to assess the association between PC and cognition in a sample of healthy adults enrolled in a cohort study.
A random sample of employees at Emory University and Georgia Institute of Technology were followed for 4 years and underwent yearly vascular and cognitive assessment (N = 430, mean age = 49.2 years, 70% women, and 27% African-American). Cognition was assessed using computerized versions of 15 cognitive tests and principal component analysis was used for deriving cognitive scores: executive function, memory and working memory. PC were defined as mononuclear cells with specific surface markers (7 phenotypes). Decreased cognition in a domain was defined as performing below the lowest quartile for the corresponding domain at baseline. Generalized estimating equations were used to investigate associations between PC and cognition.
Higher PC levels at baseline were associated with lower risk of cognitive decline in the executive and working memory domains during the follow-up period (P < 0.002 for all PC phenotypes). Further, the degree of decline in PC over the follow-up period was correlated with a corresponding decline in performances in all 3 cognitive domains over the same period (All P < 0.002).
Lower PC and greater yearly declines in PC are associated with greater cognitive decline. These findings suggest the role for PC in neurocognitive aging.
认知障碍和心血管疾病有许多共同的危险因素。血液中较高水平的骨髓源性祖细胞（PC）与较低的心血管事件发生率相关，但PC与认知功能之间的关联尚不清楚。本研究的目的是评估在一项队列研究中纳入的健康成年人样本中PC与认知之间的关联。
对埃默里大学和佐治亚理工学院的员工进行随机抽样，随访4年，并每年进行血管和认知评估（N = 430，平均年龄 = 49.2岁，70%为女性，27%为非裔美国人）。使用15项认知测试的计算机化版本评估认知，并采用主成分分析得出认知分数：执行功能、记忆和工作记忆。PC被定义为具有特定表面标志物的单核细胞（7种表型）。一个领域的认知能力下降被定义为在基线时该领域的表现低于最低四分位数。使用广义估计方程来研究PC与认知之间的关联。
基线时较高的PC水平与随访期间执行功能和工作记忆领域认知能力下降的风险较低相关（所有PC表型的P < 0.002）。此外，随访期间PC下降的程度与同期所有3个认知领域表现的相应下降相关（所有P < 0.002）。
较低的PC水平以及PC每年更大幅度的下降与更大程度的认知能力下降相关。这些发现提示了PC在神经认知衰老中的作用。
