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用于生物医学纳米颗粒的工程化海洋衍生聚合物的前景

Perspectives of Engineered Marine Derived Polymers for Biomedical Nanoparticles.

作者信息

Tran Khanh Thi My, Vo Toi Van, Duan Wei, Tran Phuong Ha-Lien, Tran Thao Truong-Dinh

机构信息

Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University - Ho Chi Minh City, Vietnam.

出版信息

Curr Pharm Des. 2016;22(19):2844-56. doi: 10.2174/1381612822666160217124735.

Abstract

Marine environment exhibits an enormous diversity of organisms which contains an abundant source of polysaccharides. As polymer matrix carriers, marine-based polymers possess several valuable properties including high stability, non-toxicity, hydrophilicity, biodegradability, with low production cost. Despite notable biological activities of these natural polymers, there are certain limitations in exploring their functions in applications of nano-sized drug delivery systems. The review aims to demonstrate exceptional characteristics of marine-based polymers including fucoidan, alginate, carrageenan, hyaluronic acid, chondroitin sulfate, and chitosan as well as provide perspectives of current publications on their nanoparticle formulations for biomedical applications.

摘要

海洋环境中生物种类极为多样,富含多糖来源。作为聚合物基质载体,海洋基聚合物具有多种宝贵特性,包括高稳定性、无毒、亲水性、生物可降解性以及低成本。尽管这些天然聚合物具有显著的生物活性,但在探索其在纳米级药物递送系统应用中的功能时仍存在一定局限性。本综述旨在展示包括岩藻聚糖、海藻酸盐、角叉菜胶、透明质酸、硫酸软骨素和壳聚糖在内的海洋基聚合物的卓越特性,并提供当前关于其用于生物医学应用的纳米颗粒制剂的出版物观点。

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