Sivashankari P R, Prabaharan M
Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India.
Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India.
Int J Biol Macromol. 2016 Dec;93(Pt B):1382-1389. doi: 10.1016/j.ijbiomac.2016.02.043. Epub 2016 Feb 17.
Tissue engineering is concerned about the rejuvenation and restoration of diseased and damages tissues/organs using man-made scaffolds that mimic the native environment of the cells. In recent years, a variety of biocompatible and biodegradable natural materials is employed for the fabrication of such scaffolds. Of these natural materials, chitosan is the most preferred one as it imitates the extracellular matrix (ECM) of the cells. Moreover, chitosan-based materials are pro-angiogenic and have antibacterial activity. These materials can be easily fabricated into the desired shape of the scaffolds that are suitable for tissue support and regeneration. Growth factors are small proteins/peptides that support and enhance the growth and differentiation of cells into a specific lineage. It has been observed that scaffolds capable of delivering growth factor promote tissue repair and regeneration at a faster rate when compared to scaffolds without growth factor. The present review focuses on the recent developments on chitosan-based scaffolds for the delivery of growth factors thereby improving and enhancing tissue regeneration.
组织工程关注的是利用模仿细胞天然环境的人造支架来使患病和受损的组织/器官恢复活力并实现修复。近年来，多种生物相容性和可生物降解的天然材料被用于制造此类支架。在这些天然材料中，壳聚糖是最受青睐的一种，因为它模仿细胞的细胞外基质（ECM）。此外，基于壳聚糖的材料具有促血管生成作用且有抗菌活性。这些材料能够轻松制成适合组织支撑和再生的所需支架形状。生长因子是支持并增强细胞生长和分化为特定谱系的小蛋白质/肽。据观察，与不含生长因子的支架相比，能够递送生长因子的支架能以更快的速度促进组织修复和再生。本综述聚焦于基于壳聚糖的用于递送生长因子从而改善和增强组织再生的支架的最新进展。
