Saravanan S, Leena R S, Selvamurugan N
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India.
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India.
Int J Biol Macromol. 2016 Dec;93(Pt B):1354-1365. doi: 10.1016/j.ijbiomac.2016.01.112. Epub 2016 Feb 1.
The clinical demand for scaffolds and the diversity of available polymers provide freedom in the fabrication of scaffolds to achieve successful progress in bone tissue engineering (BTE). Chitosan (CS) has drawn much of the attention in recent years for its use as graft material either as alone or in a combination with other materials in BTE. The scaffolds should possess a number of properties like porosity, biocompatibility, water retention, protein adsorption, mechanical strength, biomineralization and biodegradability suited for BTE applications. In this review, CS and its properties, and the role of CS along with other polymeric and ceramic materials as scaffolds for bone tissue repair applications are highlighted.
对支架的临床需求以及可用聚合物的多样性为支架制造提供了自由度，以在骨组织工程（BTE）中取得成功进展。壳聚糖（CS）近年来因其在BTE中单独或与其他材料组合用作移植材料而备受关注。支架应具备许多适合BTE应用的特性，如孔隙率、生物相容性、保水性、蛋白质吸附、机械强度、生物矿化和生物降解性。在本综述中，重点介绍了CS及其特性，以及CS与其他聚合物和陶瓷材料作为骨组织修复应用支架的作用。
