血清抵抗素水平可能会增加急性脑梗死的风险。
Serum Resistin Levels May Contribute to an Increased Risk of Acute Cerebral Infarction.
作者信息
Dong Xiao-Liu, Xu Shi-Jun, Zhang Li, Zhang Xiu-Qing, Liu Ting, Gao Qiu-Yan, Qian Qing-Qiang, Sun Bao-Liang, Yang Ming-Feng
机构信息
Department of Neurology, Tangshan People's Hospital, No. 65 Shengli Road, Lunan District, Tangshan, 063000, People's Republic of China.
Department of Neurosurgery, Tangshan People's Hospital, Tangshan, 063000, People's Republic of China.
出版信息
Mol Neurobiol. 2017 Apr;54(3):1919-1926. doi: 10.1007/s12035-016-9751-3. Epub 2016 Feb 22.
The objective of this study was to investigate the association between serum resistin levels and acute cerebral infarction (ACI). PubMed, SpringerLink, Wiley, EBSCO, Ovid, Web of Science, Wanfang, China National Knowledge Infrastructure, and VIP databases (last updated search in October 2014) were exhaustively searched, and data from the eligible studies were extracted and analyzed to assess the association between serum resistin levels and ACI. STATA software (version 12.0, Stata Corporation, College Station, TX, USA) was utilized for data analysis. Ten studies including 1829 ACI patients and 1557 healthy controls were eligible for inclusion in the meta-analysis. Our major result revealed that ACI patients exhibited higher serum resistin levels compared with healthy controls. Asubgroup analysis based on ethnicity showed a significant association between serum resistin levels and ACI in Asians, but surprisingly not in Caucasians. The results of our meta-analysis suggest that serum resistin levels are associated with an increased risk of ACI.
本研究的目的是调查血清抵抗素水平与急性脑梗死（ACI）之间的关联。我们全面检索了PubMed、SpringerLink、Wiley、EBSCO、Ovid、Web of Science、万方、中国知网和维普数据库（最后一次更新检索时间为2014年10月），并提取和分析符合条件的研究数据，以评估血清抵抗素水平与ACI之间的关联。使用STATA软件（版本12.0，美国德克萨斯州大学站市Stata公司）进行数据分析。十项研究共纳入1829例ACI患者和1557例健康对照，符合纳入荟萃分析的条件。我们的主要结果显示，与健康对照相比，ACI患者的血清抵抗素水平更高。基于种族的亚组分析显示，亚洲人的血清抵抗素水平与ACI之间存在显著关联，但令人惊讶的是，在白种人中并非如此。我们的荟萃分析结果表明，血清抵抗素水平与ACI风险增加有关。
Zotero 插件