肥胖导致老年人认知障碍：微血管观点。
Obesity-induced cognitive impairment in older adults: a microvascular perspective.
机构信息
Vascular Cognitive Impairment and Neurodegeneration Program, Department of Biochemistry and Molecular Biology, Center for Geroscience and Healthy Brain Aging/Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
International Training Program in Geroscience, Theoretical Medicine Doctoral School, Departments of Medical Physics and Informatics & Cell Biology and Molecular Medicine, University of Szeged, Szeged, Hungary.
出版信息
Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H740-H761. doi: 10.1152/ajpheart.00736.2020. Epub 2020 Dec 18.
Abstract
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
摘要
超过三分之二的 65 岁及以上的美国老年人肥胖或超重。流行病学数据显示，老年人的肥胖程度与认知功能障碍之间存在关联。在这篇综述中，考虑了微血管机制的病理生理作用，包括内皮功能障碍和神经血管耦联反应、微血管稀疏和血脑屏障破坏，这些机制在老年肥胖认知障碍的发生中起作用。讨论了脂肪衍生因子的潜在贡献以及衰老的基本细胞和分子机制，这些机制加剧了肥胖引起的大脑微血管损伤和衰老过程中的认知能力下降。
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