Sinagra Emanuele, Pompei Giancarlo, Tomasello Giovanni, Cappello Francesco, Morreale Gaetano Cristian, Amvrosiadis Georgios, Rossi Francesca, Lo Monte Attilio Ignazio, Rizzo Aroldo Gabriele, Raimondo Dario
Emanuele Sinagra, Francesca Rossi, Dario Raimondo, Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy.
World J Gastroenterol. 2016 Feb 21;22(7):2242-55. doi: 10.3748/wjg.v22.i7.2242.
Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
低度肠道炎症在肠易激综合征（IBS）的病理生理学中起关键作用，且这一作用可能是多因素的。本综述的目的是总结关于IBS黏膜炎症谱的证据，突出这种炎症与IBS病理生理学的关系及其与临床实践的联系。我们在1966年1月至2014年12月期间对Medline和Cochrane图书馆进行了文献检索，重点关注描述炎症与IBS之间相互作用的出版物。多项证据表明IBS患者存在微观和分子异常。了解IBS中低度炎症的潜在机制可能有助于设计临床试验，以测试针对这一病理生理机制的药物的疗效和安全性。
