Tachai Sirichan, Nuntawong Nuchnipa
a Faculty of Science, Department of Chemistry and Centre for Innovation in Chemistry , Chiang Mai University , Chiang Mai , Thailand.
Nat Prod Res. 2016 Oct;30(19):2215-9. doi: 10.1080/14786419.2016.1146884. Epub 2016 Feb 22.
From the rhizomes of Etlingera pavieana (Pierre ex Gagnep.) R.M. Sm., four phenylpropens, (E)-3-(4-methoxyphenyl)prop-2-en-1-amine (1), (E)-4-methoxycinamaldehyde (2), (E)-4-methoxycinamic acid (3) and (E)-1-methoxy-4-(3-methoxyprop-1-enyl)benzene (4), together with two other compounds, (E)-((E)-3-(4-methoxyphenyl)allyl)3-(4-hydroxyphenyl)acrylate (5) and 4-methoxybenzoic acid (6) were isolated. This is the first report on the presence of all compounds in Etlingera. Compounds 1 and 5 have been previously synthesised, but this is the first report of their isolation from a natural source. Compound 5 exhibited weak activity against Mycobacterium tuberculosis with MIC 50.00 μg/mL and cytotoxic activity against the KB, MCF7 and NCI-H187 cells with IC50 values of 25.11, 20.16 and 34.83 μg/mL, respectively.
从长柄山姜（Etlingera pavieana (Pierre ex Gagnep.) R.M. Sm.）的根茎中，分离出了四种苯丙烯类化合物，即(E)-3-(4-甲氧基苯基)丙-2-烯-1-胺（1）、(E)-4-甲氧基肉桂醛（2）、(E)-4-甲氧基肉桂酸（3）和(E)-1-甲氧基-4-(3-甲氧基丙-1-烯基)苯（4），以及另外两种化合物，(E)-((E)-3-(4-甲氧基苯基)烯丙基)3-(4-羟基苯基)丙烯酸酯（5）和4-甲氧基苯甲酸（6）。这是首次关于长柄山姜中所有这些化合物存在的报道。化合物1和5此前已被合成，但这是它们首次从天然来源中分离得到的报道。化合物5对结核分枝杆菌表现出微弱活性，MIC为50.00 μg/mL，对KB、MCF7和NCI-H187细胞具有细胞毒性活性，IC50值分别为25.11、20.16和34.83 μg/mL。
