Han Ah-Reum, Min Hye-Young, Windono Tri, Jeohn Gwang-Ho, Jang Dae Sik, Lee Sang Kook, Seo Eun-Kyoung
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Planta Med. 2004 Nov;70(11):1095-7. doi: 10.1055/s-2004-832656.
A new phenylbutenoid dimer, (+/-)- trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (+/-)- trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including 1D and 2D NMR experiments.
从高良姜的根茎中分离出一种新的苯基丁烯类二聚体，（±）-反式-3-（4-羟基-3-甲氧基苯基）-4- [（E）-3,4-二甲氧基苯乙烯基]环己-1-烯，以及三种已知化合物，（±）-反式-3-（3,4-二甲氧基苯基）-4- [（E）-3,4-二甲氧基苯乙烯基]环己-1-烯、4-（3,4-二甲氧基苯基）丁-1,3-二烯和4-（2,4,5-三甲氧基苯基）丁-1,3-二烯，采用A549人癌细胞系细胞毒性试验通过生物活性导向分级分离法进行分离。通过光谱分析，包括一维和二维核磁共振实验，阐明了新化合物的结构。
