Ito Yuri, Nakaya Tomoki, Ioka Akiko, Nakayama Tomio, Tsukuma Hideaki, Uehara Shinichiro, Kogawa Sato Kyoko, Endo Ginji, Hayashi Tomoshige
Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases.
J Epidemiol. 2016 Sep 5;26(9):459-63. doi: 10.2188/jea.JE20150116. Epub 2016 Feb 20.
In 2013, an unusually high incidence of biliary tract cancer among current or former workers of the offset color proof printing department of a printing company in Osaka, Japan, was reported. The purpose of this study was to examine whether distance from the printing factory was associated with incidence of biliary tract cancer and whether incident biliary tract cancer cases clustered around the printing factory in Osaka using population-based cancer registry data.
We estimated the age-standardized incidence ratio of biliary tract cancer according to distance from this printing factory. We also searched for clusters of biliary tract cancer incidence using spatial scan statistics.
We did not observe statistically significantly high or low standardized incidence ratios for residents in each area categorized by distance from the printing factory for the entire sample or for either sex. The scan statistics did not show any statistically significant clustering of biliary tract cancer incidence anywhere in Osaka prefecture in 2004-2007.
There was no statistically significant clustering of biliary tract cancer incidence around the printing factory or in any other areas in Osaka, Japan, between 2004 and 2007. To date, even if some substances have diffused outside this source factory, they do not appear to have influenced the incidence of biliary tract cancer in neighboring residents.
2013年，有报道称日本大阪一家印刷公司胶版彩色打样部门的在职或离职员工中，胆管癌发病率异常高。本研究的目的是利用基于人群的癌症登记数据，调查与印刷厂的距离是否与胆管癌发病率相关，以及大阪的胆管癌发病病例是否在印刷厂周围聚集。
我们根据与这家印刷厂的距离，估算了胆管癌的年龄标准化发病率比。我们还使用空间扫描统计方法寻找胆管癌发病率的聚集情况。
对于整个样本或任何一个性别的人群，我们并未观察到按与印刷厂的距离划分的各个区域居民的标准化发病率有统计学上的显著偏高或偏低情况。扫描统计结果未显示2004 - 2007年大阪府任何地方的胆管癌发病率有任何统计学上的显著聚集情况。
2004年至2007年期间，日本大阪的印刷厂周围或任何其他区域均未出现统计学上显著的胆管癌发病率聚集情况。迄今为止，即使某些物质已从这家源头工厂扩散出去，它们似乎也未对周边居民的胆管癌发病率产生影响。
