Sampat Hemal N, McAllister Brian P, Gaines Darryl D, Ostrov Barbara
From the *Department of Pediatrics, Penn State Hershey Children's Hospital; and †Department of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
J Clin Rheumatol. 2016 Mar;22(2):82-5. doi: 10.1097/RHU.0000000000000361.
Henoch-Schönlein purpura (HSP), more recently termed immunoglobulin A (IgA) vasculitis, is a systemic small-vessel vasculitis characterized by perivascular IgA deposition. This disease manifests clinically as palpable purpura, arthralgia, gastrointestinal symptoms, and renal dysfunction. Although ileitis can be seen in HSP, terminal ileitis is virtually pathognomonic for Crohn disease. We present a comprehensive review of the literature on this association, including 2 cases of our own, to demonstrate the importance of considering HSP in the differential diagnosis of ileitis suggestive of Crohn disease. We review the growing body of literature suggesting a pathophysiologic link between the conditions, possibly through an IgA-mediated mechanism.
过敏性紫癜（HSP），最近被称为免疫球蛋白A（IgA）血管炎，是一种系统性小血管炎，其特征为血管周围IgA沉积。这种疾病在临床上表现为可触及的紫癜、关节痛、胃肠道症状和肾功能障碍。虽然在过敏性紫癜中可见回肠炎，但末端回肠炎实际上是克罗恩病的特征性表现。我们对关于这种关联的文献进行了全面综述，包括我们自己的2例病例，以证明在疑似克罗恩病的回肠炎鉴别诊断中考虑过敏性紫癜的重要性。我们回顾了越来越多的文献，这些文献表明这两种疾病之间可能通过IgA介导的机制存在病理生理联系。
