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[采用带血管自体神经移植修复神经缺损后的神经再生]

[Nerve regeneration after correction of its defect with a vascularized autologous nerve transplant].

作者信息

Popovich M I, Belousov A E

出版信息

Arkh Anat Gistol Embriol. 1989 Sep;97(9):47-51.

PMID:2690777
Abstract

In chronic experiment performed on 6 dogs, by means of some neurohistological techniques peculiarities of regeneration of nerves have been studied, when their defects are substituted for vascularized and common autoneurotransplants. When the vascularized autoneurotransplants are applied, more favourable conditions are made for the nerve regeneration, than at a free plastisity and amount of regenerated fibers distal to the graft reaches 34-88%, more often making 48-52% of the initial number of fibers in the proximal parts of the nerves in 3 months after the operation. When in the same animals in the contralateral side common autoneurotransplants have been applied, during the same time the amount of fibers regenerated into the peripheral parts of the nerves makes 10-26%, more often 17-20% from the initial level, or in 2-2.5 times less than at substitution of the defects for the vascularized grafts. Absence of an active cellular reaction of the surrounding tissues to the sutural material supramid is used.

摘要

在对6只狗进行的慢性实验中,借助一些神经组织学技术,研究了在神经缺损被血管化自体神经移植和普通自体神经移植替代时神经再生的特点。应用血管化自体神经移植时,为神经再生创造了更有利的条件,与自由可塑性相比,移植远端再生纤维的数量和比例达到34%-88%,术后3个月时,更多情况下为近端神经纤维初始数量的48%-52%。当在同一只动物的对侧应用普通自体神经移植时,在相同时间内,向神经外周部分再生的纤维数量为初始水平的10%-26%,更多情况下为17%-20%,比用血管化移植替代缺损时少2-2.5倍。使用的缝合材料Supramid周围组织无活跃细胞反应。

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