CAMH Research Imaging Centre, Canada; Campbell Family Mental Health Research Institute, CAMH, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada.
Institute of Medical Science, University of Toronto, Canada; University Health Network, Canada.
Eur Neuropsychopharmacol. 2016 Apr;26(4):777-86. doi: 10.1016/j.euroneuro.2015.12.030. Epub 2015 Dec 21.
Impulsivity is a core feature of antisocial personality disorder (ASPD) associated with abnormal brain function and neurochemical alterations. The ventral striatum (VS) is a key region of the neural circuitry mediating impulsive behavior, and low monoamine oxidase-A (MAO-A) level in the VS has shown a specific relationship to the impulsivity of ASPD. Because it is currently unknown whether phenotypic MAO-A markers can influence brain function in ASPD, we investigated VS MAO-A level and the functional connectivity (FC) of two seed regions, superior and inferior VS (VSs, VSi). Nineteen impulsive ASPD males underwent [(11)C] harmine positron emission tomography scanning to measure VS MAO-A VT, an index of MAO-A density, and resting-state functional magnetic resonance imaging that assessed the FC of bilateral seed regions in the VSi and VSs. Subjects also completed self-report impulsivity measures. Results revealed functional coupling of the VSs with bilateral dorsomedial prefrontal cortex (DMPFC) that was correlated with VS MAO-A VT (r=0.47, p=0.04), and functional coupling of the VSi with right hippocampus that was anti-correlated with VS MAO-A VT (r=-0.55, p=0.01). Additionally, VSs-DMPFC FC was negatively correlated with NEO Personality Inventory-Revised impulsivity (r=-0.49, p=0.03), as was VSi-hippocampus FC with Barratt Impulsiveness Scale-11 motor impulsiveness (r=-0.50, p=0.03). These preliminary results highlight an association of VS MAO-A level with the FC of striatal regions linked to impulsive behavior in ASPD and suggest that phenotype-based brain markers of ASPD have relevance to understanding brain function.
冲动性是反社会人格障碍（ASPD）的核心特征，与大脑功能异常和神经化学改变有关。腹侧纹状体（VS）是介导冲动行为的神经回路的关键区域，VS 中的单胺氧化酶-A（MAO-A）水平较低与 ASPD 的冲动性有特定关系。由于目前尚不清楚表型 MAO-A 标志物是否会影响 ASPD 中的大脑功能，我们研究了 VS MAO-A 水平和两个种子区域（上、下 VS [VSs，VSi]）的功能连接（FC）。19 名冲动性 ASPD 男性接受了 [(11)C] harmine 正电子发射断层扫描以测量 VS MAO-A VT，这是 MAO-A 密度的指标，以及静息状态功能磁共振成像，评估双侧 VSi 和 VSs 种子区域的 FC。受试者还完成了自我报告的冲动性测量。结果显示，VSs 与双侧背内侧前额叶皮层（DMPFC）的功能耦合与 VS MAO-A VT 相关（r=0.47，p=0.04），VSi 与右侧海马的功能耦合与 VS MAO-A VT 呈负相关（r=-0.55，p=0.01）。此外，VSs-DMPFC FC 与 NEO 人格量表修订版冲动性呈负相关（r=-0.49，p=0.03），VSi-海马 FC 与 Barratt 冲动量表-11 运动冲动性呈负相关（r=-0.50，p=0.03）。这些初步结果强调了 VS MAO-A 水平与与 ASPD 中与冲动行为相关的纹状体区域的 FC 之间的关联，并表明 ASPD 的基于表型的大脑标志物与理解大脑功能有关。
