[环境中有机微污染物的致突变性。III. 所选除草剂和杀虫剂在SOS色变试验中的致突变性]
[The mutagenicity of organic microcontamination in the environment. III. The mutagenicity of selected herbicides and insecticides in the SOS chromotest].
作者信息
Mersch-Sundermann V, Hofmeister A, Müller G, Hof H
机构信息
Institut für Hygiene und Medizinische Mikrobiologie der Fakultät für Klinische Medizin Mannheim der Ruprecht-Karls-Universität Heidelberg.
出版信息
Zentralbl Hyg Umweltmed. 1989 Nov;189(2):135-46.
To determine the mutagenicity of selected herbicides and insecticides we examined 26 pure pesticide substances (polychlorinated alicyclic hydrocarbons, phenoxy fatty acids, triazines) with the help of SOS-Chromotest. We used Escherichia coli strain PQ37 in these tests without and with metabolic activation with Aroclor 1254 induced rat liver microsome fraction. None of the substances showed a provable induction of the E. coli-SOS-system, because a great number of the pesticides showed toxic effects against bacteria in high concentrations.
为了确定所选除草剂和杀虫剂的致突变性，我们借助SOS色测试法检测了26种纯农药物质（多氯代脂环烃、苯氧基脂肪酸、三嗪）。在这些测试中，我们使用了大肠杆菌菌株PQ37，分别在无代谢活化以及有经Aroclor 1254诱导的大鼠肝微粒体组分进行代谢活化的情况下进行检测。由于大量农药在高浓度时对细菌显示出毒性作用，所以没有一种物质能证明可诱导大肠杆菌SOS系统。
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