Mersch-Sundermann V, Dickgiesser N, Hablizel U, Gruber B
Institut für Medizinische Mikrobiologie und Hygiene der Fakultät für Klinische Medizin Mannheim der Ruprecht-Karls-Universität Heidelberg.
Zentralbl Bakteriol Mikrobiol Hyg B Umwelthyg Krankenhaushyg Arbeitshyg Prav Med. 1988 Jun;186(3):247-60.
For determination of the mutagenicity of herbicides and insecticides in working and environmental relevant concentrations we examined 26 pure substances of the chemical groups of polychlorinated alicyclic hydrocarbons, phenoxy fatty acids and and triazines with the Salmonella-microsome-test (S. typhimurium strains TA 97, TA 98, TA 100 and TA 102 with and without metabolic activation with Aroclor 1254 induced rat liver microsome fraction). Only one substance--Chlorthiamide--showed mutagenicity in concentrations of 0.001 microgram/plate. In all the other substances examined we found numbers of revertants near the spontaneous mutagenic rates. However a human carcinogenic potential can't be excluded, because several toxicological studies with mammalians showed a carcinogenic activity of organohalogenic insecticides without mutagenic activity in biological short term tests.
为了测定除草剂和杀虫剂在工作场所及环境相关浓度下的致突变性，我们使用沙门氏菌-微粒体试验（鼠伤寒沙门氏菌TA 97、TA 98、TA 100和TA 102菌株，有或无经Aroclor 1254诱导的大鼠肝微粒体组分代谢活化）检测了多氯代脂环烃、苯氧基脂肪酸和三嗪这几类化学物质中的26种纯物质。只有一种物质——氯硫酰胺——在浓度为0.001微克/平板时表现出致突变性。在所有其他检测的物质中，我们发现回复突变体数量接近自发突变率。然而，不能排除其对人类的致癌潜力，因为多项针对哺乳动物的毒理学研究表明，有机卤代杀虫剂具有致癌活性，但在生物短期试验中无致突变活性。
