Kwon Hyun Woo, Kim Jong Phil, Lee Hong Jae, Paeng Jin Chul, Lee Jae Sung, Cheon Gi Jeong, Lee Dong Soo, Chung June-Key, Kang Keon Wook
Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Molecular Medicine and Biopharmaceutical Science, Graduate school of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea .
J Korean Med Sci. 2016 Feb;31 Suppl 1(Suppl 1):S69-74. doi: 10.3346/jkms.2016.31.S1.S69. Epub 2016 Feb 3.
The purpose of this study was to estimate average radiation exposure from (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) examinations and to analyze possible factors affecting the radiation dose. A nation-wide questionnaire survey was conducted involving all institutions that operate PET/CT scanners in Korea. From the response, radiation doses from injected FDG and CT examination were calculated. A total of 105 PET/CT scanners in 73 institutions were included in the analysis (response rate of 62.4%). The average FDG injected activity was 310 ± 77 MBq and 5.11 ± 1.19 MBq/kg. The average effective dose from FDG was estimated to be 5.89 ± 1.46 mSv. The average CT dose index and dose-length product were 4.60 ± 2.47 mGy and 429.2 ± 227.6 mGy∙cm, which corresponded to 6.26 ± 3.06 mSv. The radiation doses from FDG and CT were significantly lower in case of newer scanners than older ones (P < 0.001). Advanced PET technologies such as time-of-flight acquisition and point-spread function recovery were also related to low radiation dose (P < 0.001). In conclusion, the average radiation dose from FDG PET/CT is estimated to be 12.2 mSv. The radiation dose from FDG PET/CT is reduced with more recent scanners equipped with image-enhancing algorithms.
本研究的目的是估算¹⁸F-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）检查的平均辐射暴露量，并分析影响辐射剂量的可能因素。在韩国，对所有运营PET/CT扫描仪的机构进行了一项全国性问卷调查。根据回复，计算了注射FDG和CT检查的辐射剂量。分析纳入了73家机构的105台PET/CT扫描仪（回复率为62.4%）。FDG的平均注射活度为310±77 MBq，即5.11±1.19 MBq/kg。FDG的平均有效剂量估计为5.89±1.46 mSv。CT剂量指数和剂量长度乘积的平均值分别为4.60±2.47 mGy和429.2±227.6 mGy∙cm，相当于6.26±3.06 mSv。新型扫描仪的FDG和CT辐射剂量显著低于旧型扫描仪（P<0.001）。飞行时间采集和点扩散函数恢复等先进PET技术也与低辐射剂量有关（P<0.001）。总之，FDG PET/CT的平均辐射剂量估计为12.2 mSv。配备图像增强算法的新型扫描仪可降低FDG PET/CT的辐射剂量。
