Tao Jing, Liu Jiao, Egorova Natalia, Chen Xiangli, Sun Sharon, Xue Xiehua, Huang Jia, Zheng Guohua, Wang Qin, Chen Lidian, Kong Jian
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Fujian Key Laboratory of Rehabilitation of Technology, Fuzhou, China; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine , Fuzhou , China.
Front Aging Neurosci. 2016 Feb 16;8:25. doi: 10.3389/fnagi.2016.00025. eCollection 2016.
Previous studies provide evidence that aging is associated with the decline of memory function and alterations in the hippocampal (HPC) function, including functional connectivity to the medial prefrontal cortex (mPFC). In this study, we investigated if longitudinal (12-week) Tai Chi Chuan and Baduanjin practice can improve memory function and modulate HPC resting-state functional connectivity (rs-FC). Memory function measurements and resting-state functional magnetic resonance imaging (rs-fMRI) were applied at the beginning and the end of the experiment. The results showed that (1) the memory quotient (MQ) measured by the Wechsler Memory Scale-Chinese Revision significantly increased after Tai Chi Chuan and Baduanjin practice as compared with the control group, and no significant difference was observed in MQ between the Tai Chi Chuan and Baduanjin groups; (2) rs-FC between the bilateral hippocampus and mPFC significantly increased in the Tai Chi Chuan group compared to the control group (also in the Baduanjin group compared to the control group, albeit at a lower threshold), and no significant difference between the Tai Chi Chuan and Baduanjin groups was observed; (3) rs-FC increases between the bilateral hippocampus and mPFC were significantly associated with corresponding memory function improvement across all subjects. Similar results were observed using the left or right hippocampus as seeds. Our results suggest that both Tai Chi Chuan and Baduanjin may be effective exercises to prevent memory decline during aging.
先前的研究表明，衰老与记忆功能衰退以及海马体（HPC）功能改变有关，包括与内侧前额叶皮质（mPFC）的功能连接。在本研究中，我们调查了为期12周的太极拳和八段锦练习是否能改善记忆功能并调节HPC静息态功能连接（rs-FC）。在实验开始和结束时进行了记忆功能测量和静息态功能磁共振成像（rs-fMRI）。结果显示：（1）与对照组相比，太极拳和八段锦练习后，用韦氏记忆量表中文版测得的记忆商（MQ）显著提高，且太极拳组和八段锦组之间的MQ无显著差异；（2）与对照组相比，太极拳组双侧海马体与mPFC之间的rs-FC显著增加（八段锦组与对照组相比也有增加，尽管阈值较低），且太极拳组和八段锦组之间无显著差异；（3）在所有受试者中，双侧海马体与mPFC之间的rs-FC增加与相应的记忆功能改善显著相关。以左侧或右侧海马体为种子时也观察到了类似结果。我们的结果表明，太极拳和八段锦都可能是预防衰老过程中记忆衰退的有效运动。
