Zhong Jia-Ling, Huang Chang-Zhi
Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
World J Gastrointest Oncol. 2016 Feb 15;8(2):198-206. doi: 10.4251/wjgo.v8.i2.198.
The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design.
泛素蛋白酶体系统（UPS）对真核细胞中的蛋白质降解很重要。它几乎参与了每一个细胞过程，并在维持机体稳态中发挥重要作用。越来越多的证据表明，UPS的改变与胃肠道恶性肿瘤有关，包括食管癌、胃癌和结直肠癌。在这里，我们总结了当前详细阐述UPS参与胃肠道癌症的文献，强调其在肿瘤发生和发展中的作用，为治疗靶点研究和抗胃肠道肿瘤药物设计提供信息。
