Duman Nilay, Duman Reşat, Yavaş Güliz Fatma, Doğruk Kaçar Seval, Özuğuz Pınar, Çetinkaya Ersan
a Department of Dermatology and.
b Department of Ophthalmology , School of Medicine, Afyon Kocatepe University , Afyonkarahisar , Turkey , and.
Cutan Ocul Toxicol. 2017 Mar;36(1):9-11. doi: 10.3109/15569527.2016.1140179. Epub 2016 Feb 24.
Although topical prostaglandin analogs (PGAs) have been previously associated with periocular skin hyperpigmentation, studies using objective clinical methods are lacking. Furthermore changes in periocular skin erythema indexes associated with topical PGAs have not been reported previously.
The purpose of the present study was to evaluate periocular melanin and erythema indexes in patients treated with topical PGA using an objective clinical method - Mexameter.
About 45 glaucoma patients treated with topical PGA therapy, and 30 age-, and sex-matched controls were enrolled in the study. Demographic data, medical history including duration of therapy, PGA type, involved eye (unilateral, bilateral) were noted, and skin phototypes were evaluated. Melanin and erythema indexes on medial and lateral upper and lower eyelids, and normal skin from the upper cheeks were measured using Mexameter MX-18. The index of difference for lower/upper eyelid was calculated. Reading results of patients and controls were compared.
Melanin and erythema indexes of upper/lower eyelids, and the index of differences for upper/lower eyelids were significantly higher in patients despite similar clinical findings (p < 0.05). Duration of therapy and type of PGA were not associated with skin changes (p > 0.05).
Both periocular melanin and erythema indexes increased in both upper and lower eyelids due to PGA therapy compared to controls, despite similar clinical findings. Mexametric evaluation is more sensitive than clinical evaluation, and may be used as an objective, sensitive clinical method to evaluate periocular skin changes, even smallest changes, in such patients.
尽管局部用前列腺素类似物（PGAs）此前已被认为与眼周皮肤色素沉着有关，但缺乏使用客观临床方法的研究。此外，此前尚未报道过与局部用PGAs相关的眼周皮肤红斑指数变化。
本研究的目的是使用客观临床方法——Mexameter评估接受局部用PGA治疗的患者的眼周黑色素和红斑指数。
约45例接受局部用PGA治疗的青光眼患者以及30例年龄和性别匹配的对照者纳入本研究。记录人口统计学数据、包括治疗持续时间的病史、PGA类型、受累眼（单侧、双侧），并评估皮肤光型。使用Mexameter MX-18测量上睑和下睑内侧及外侧以及上脸颊正常皮肤的黑色素和红斑指数。计算下睑/上睑的差异指数。比较患者和对照者的读数结果。
尽管临床结果相似，但患者的上睑/下睑黑色素和红斑指数以及上睑/下睑差异指数显著更高（p<0.05）。治疗持续时间和PGA类型与皮肤变化无关（p>0.05）。
与对照者相比，尽管临床结果相似，但由于PGA治疗，上睑和下睑的眼周黑色素和红斑指数均升高。Mexametric评估比临床评估更敏感，可作为评估此类患者眼周皮肤变化（即使是最小变化）的客观、敏感的临床方法。
