Al-Zobidi Mohammed, Khandekar Rajiv, Cruz Augusto, Craven Randy E, Souru Ches, Malik Rizwan, Edward Deepak P
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
J AAPOS. 2018 Aug;22(4):290-293.e1. doi: 10.1016/j.jaapos.2018.01.019. Epub 2018 May 21.
To compare pretarsal skin height (PTSH), as proxy indicator of deepening of the upper eyelid sulcus, in children with primary congenital glaucoma (PCG) treated with topical prostaglandin analogues (PGAs) with PTSH in healthy children (control group 1) and children with PCG but not using PGAs (control group 2).
We recruited children with PCG who had been using PGAs for at least 6 months (PCG/PGA group). PTSH in all participants was measured using ImageJ software from photographs taken in a standardized manner. The PTSH was compared for the PCG group and both control groups.
A total of 34 children with PCG and 41 controls (31 in group 1; 10 in group 2) were included. The difference in PTSH between children in the PCG/PGA group and both control groups was statistically significant (mean difference, ≥1.7 mm [P < 0.01]).
The PTSH was significantly greater in children with PCG using PGAs compared to children with PCG not using PGAs and healthy children. Children and their parents should be counseled about lid abnormalities prior to commencing treatment with PGAs.
比较原发性先天性青光眼（PCG）患儿使用局部前列腺素类似物（PGA）治疗后的睑前皮肤高度（PTSH）（作为上睑沟加深的替代指标）与健康儿童（对照组1）及未使用PGA的PCG患儿（对照组2）的PTSH。
我们招募了使用PGA至少6个月的PCG患儿（PCG/PGA组）。使用ImageJ软件从以标准化方式拍摄的照片中测量所有参与者的PTSH。比较PCG组与两个对照组的PTSH。
共纳入34例PCG患儿和41例对照（对照组1有31例；对照组2有10例）。PCG/PGA组患儿与两个对照组患儿的PTSH差异具有统计学意义（平均差异≥1.7毫米[P<0.01]）。
与未使用PGA的PCG患儿和健康儿童相比，使用PGA的PCG患儿的PTSH明显更高。在开始使用PGA治疗之前，应向患儿及其家长咨询眼睑异常情况。
