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一种用于随访接受假体置换和植入钽珠的患者的CT方法:骨盆模型及7例患者的初步分析

A CT method for following patients with both prosthetic replacement and implanted tantalum beads: preliminary analysis with a pelvic model and in seven patients.

作者信息

Olivecrona Henrik, Maguire Gerald Q, Noz Marilyn E, Zeleznik Michael P, Kesteris Uldis, Weidenhielm Lars

机构信息

Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176, Stockholm, Sweden.

School of Information and Communication Technology, KTH Royal Institute of Technology, Stockholm, Sweden.

出版信息

J Orthop Surg Res. 2016 Feb 24;11:27. doi: 10.1186/s13018-016-0360-7.

Abstract

BACKGROUND

Radiostereometric analysis (RSA) is often used for evaluating implanted devices over time. Following patients who have had tantalum beads implanted as markers in conjunction with joint replacements is important for longitudinal evaluation of these patients and for those with similar implants. As doing traditional RSA imaging is exacting and limited to specialized centers, it is important to consider alternative techniques for this ongoing evaluation. This paper studies the use of computed tomography (CT) to evaluate over time tantalum beads which have been implanted as markers.

METHODS

The project uses both a hip model implanted with tantalum beads, acquired in several orientations, at two different CT energy levels, and a cohort of seven patients. The model was evaluated twice by the same observer with a 1-week interval. All CT volumes were analyzed using a semi-automated 3D volume fusion (spatial registration) tool which provides landmark-based fusion of two volumes, registering a target volume with a reference volume using a rigid body 3D algorithm. The mean registration errors as well as the accuracy and repeatability of the method were evaluated.

RESULTS

The mean registration error, maximum value of repeatability, and accuracy for the relative movement in the model were 0.16 mm, 0.02° and 0.1 mm, and 0.36° and 0.13 mm for 120 kVp and 0.21 mm, 0.04° and 0.01 mm, and 0.39° and 0.12 mm for 100 kVp. For the patients, the mean registration errors per patient ranged from 0.08 to 0.35 mm. These results are comparable to those in typical clinical RSA trials. This technique successfully evaluated two patients who would have been lost from the cohort if only RSA were used.

CONCLUSIONS

The proposed technique can be used to evaluate patients with tantalum beads over time without the need for stereoradiographs. Further, the effective dose associated with CT is decreasing.

摘要

背景

放射性立体测量分析(RSA)常用于长期评估植入装置。对接受钽珠植入作为标记物并进行关节置换的患者进行随访,对于这些患者以及有类似植入物的患者的纵向评估很重要。由于传统的RSA成像要求苛刻且仅限于专业中心,因此在进行这种持续评估时考虑替代技术很重要。本文研究了使用计算机断层扫描(CT)来长期评估作为标记物植入的钽珠。

方法

该项目使用了一个植入钽珠的髋关节模型,在两个不同的CT能量水平下从多个方向获取图像,以及一组七名患者。该模型由同一名观察者在间隔1周的时间内进行了两次评估。所有CT容积均使用半自动3D容积融合(空间配准)工具进行分析,该工具提供基于地标点的两个容积融合,使用刚体3D算法将目标容积与参考容积配准。评估了平均配准误差以及该方法的准确性和可重复性。

结果

模型中相对运动的平均配准误差、重复性最大值和准确性,120 kVp时分别为0.16 mm、0.02°和0.1 mm,以及0.36°和0.13 mm;100 kVp时分别为0.21 mm、0.04°和0.01 mm,以及0.39°和0.12 mm。对于患者,每位患者的平均配准误差范围为0.08至0.35 mm。这些结果与典型的临床RSA试验结果相当。该技术成功评估了两名患者,如果仅使用RSA,这两名患者将从队列中流失。

结论

所提出的技术可用于长期评估植入钽珠的患者,而无需立体放射照片。此外,与CT相关的有效剂量正在降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087f/4766687/1988c48bf33c/13018_2016_360_Fig1_HTML.jpg

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