Rössle Matthias, Cathomas Gieri, Bonapace Laura, Sachs Melanie, Dehler Silvia, Storz Martina, Huber Gerhard, Moch Holger, Junt Tobias, Mertz Kirsten D
Institute of Pathology, Cantonal Hospital of Grisons, Chur, Switzerland.
Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
Int J Surg Pathol. 2016 Aug;24(5):394-400. doi: 10.1177/1066896916633856. Epub 2016 Feb 23.
The cytokine interleukin-33 (IL-33) is abundantly expressed in epithelial barrier tissues such as salivary glands. Here, we characterized nuclear IL-33 protein expression by immunohistochemistry in benign and malignant salivary gland tumors and associated it with disease outcome. Most benign salivary gland tumors expressed IL-33, and all Warthin's tumors showed strong and consistent IL-33 expression in the basally oriented cells of their bilayered epithelium. In the malignant group of neoplasms, nuclear IL-33 expression was limited to specific tumor entities-for example, to epithelial-myopepithelial carcinomas (n = 9/11), acinic cell carcinomas (n = 13/27), and oncocytic carcinomas (n = 2/2). IL-33 expression in the combined group of malignant salivary gland neoplasms was significantly associated with favorable histological parameters, lack of metastasis, and longer overall survival, compared with IL-33-negative tumors. We conclude that IL-33 expression is a novel prognostic marker for malignant salivary gland tumors with potential use in clinical diagnostics.
细胞因子白细胞介素-33（IL-33）在诸如唾液腺等上皮屏障组织中大量表达。在此，我们通过免疫组织化学对良性和恶性唾液腺肿瘤中的核IL-33蛋白表达进行了表征，并将其与疾病转归相关联。大多数良性唾液腺肿瘤表达IL-33，所有沃辛瘤在其双层上皮的基底定向细胞中均显示出强烈且一致的IL-33表达。在恶性肿瘤组中，核IL-33表达仅限于特定的肿瘤实体，例如上皮-肌上皮癌（n = 9/11）、腺泡细胞癌（n = 13/27）和嗜酸性细胞癌（n = 2/2）。与IL-33阴性肿瘤相比，恶性唾液腺肿瘤联合组中的IL-33表达与良好的组织学参数、无转移以及更长的总生存期显著相关。我们得出结论，IL-33表达是恶性唾液腺肿瘤的一种新型预后标志物，具有临床诊断的潜在用途。
