Shimomura K, Fukushige J, Ueda K
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Eur J Pediatr. 1989 Oct;149(1):18-9. doi: 10.1007/BF02024326.
Infants and toddlers often start crying at venopuncture and the stress of crying has been known to increase the levels of plasma renin activity (PRA) and plasma aldosterone concentration (PAC), but no precise information is available. We measured the levels of PRA and PAC in blood samples taken from 30 infants and toddlers within 1 min after the onset of crying, as induced by venopuncture, and 3 and 5 min after continuation of crying (PRA1.0, PRA3.0, PRA5.0, and PAC1.0, PAC3.0, PAC5.0). The age of these subjects ranged from 1 to 30 months (median 16 months). PRA1.0, PRA3.0 and PRA5.0 were 4.0 +/- 1.8 ng/ml per hour, 5.5 +/- 2.7 ng/ml per hour, and 7.8 +/- 4.2 ng/ml per hour, respectively. PAC1.0, PAC3.0 and PAC5.0 were 210 +/- 110 pg/ml, 231 +/- 118 pg/ml and 269 +/- 145 pg/ml, respectively. Both PRA and PAC increased with elapsing time. The increase in PRA was marked after a short episode of crying, but that in PAC was of a mild degree.
婴幼儿在静脉穿刺时常常会开始哭闹，而哭闹产生的压力已知会增加血浆肾素活性（PRA）和血浆醛固酮浓度（PAC），但尚无确切信息。我们测量了30名婴幼儿在静脉穿刺引发哭闹开始后1分钟内以及哭闹持续3分钟和5分钟后采集的血样中的PRA和PAC水平（PRA1.0、PRA3.0、PRA5.0以及PAC1.0、PAC3.0、PAC5.0）。这些受试者的年龄在1至30个月之间（中位数为16个月）。PRA1.0、PRA3.0和PRA5.0分别为每小时4.0±1.8纳克/毫升、每小时5.5±2.7纳克/毫升以及每小时7.8±4.2纳克/毫升。PAC1.0、PAC3.0和PAC5.0分别为210±110皮克/毫升、231±118皮克/毫升以及269±145皮克/毫升。PRA和PAC均随着时间推移而增加。哭闹一小段时间后PRA的增加较为明显，但PAC的增加程度较轻。
