儿童体内的肾素和血管紧张素水平。
Renin and angiotensin levels in children.
作者信息
Broughton Pipkin F, Smales O R, O'Callaghan M
出版信息
Arch Dis Child. 1981 Apr;56(4):298-302. doi: 10.1136/adc.56.4.298.
Abstract
Plasma renin activity, plasma renin concentration, and angiotensin II levels were measured in 63 normal children aged between 2 months and 12 years. The results showed that the high levels of renin and angiotensin II present in infancy remained above adult levels throughout the first decade of life but that there was a decline with age. Boys less than 8 years old had lower plasma renin activity and angiotensin II levels than girls of a similar age; this may be due to a relative substrate deficiency. Serum urea levels were inversely correlated with plasma renin activity in both sexes. A significant inverse relationship was found between both plasma renin activity and angiotensin II, and serum sodium in the girls; a similar, although not statistically significant, relationship was seen with plasma renin activity in the boys. An inverse correlation was found between plasma renin concentration and diastolic blood pressure for the group as a whole.
摘要
对63名年龄在2个月至12岁之间的正常儿童测量了血浆肾素活性、血浆肾素浓度和血管紧张素II水平。结果显示，婴儿期肾素和血管紧张素II的高水平在生命的第一个十年中一直高于成人水平，但随年龄增长而下降。8岁以下男孩的血浆肾素活性和血管紧张素II水平低于同龄女孩；这可能是由于相对底物缺乏。男女两性的血清尿素水平与血浆肾素活性呈负相关。在女孩中，血浆肾素活性和血管紧张素II与血清钠之间均存在显著负相关；在男孩中，血浆肾素活性与血清钠之间也存在类似关系，尽管无统计学意义。在整个研究组中，血浆肾素浓度与舒张压呈负相关。
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