Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.
Science. 2016 Feb 19;351(6275):854-7. doi: 10.1126/science.aad8588.
In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.
在大多数动物物种中，幼年生长的特点是体重和体型呈指数增长。在这里，我们表明，当小鼠喂食标准实验室小鼠饮食或营养缺乏饮食时，婴儿小鼠的微生物组维持体重增加和纵向生长。我们发现肠道微生物组与生长激素轴相互作用，以驱动全身生长。使用单定植的小鼠模型，我们表明，选定的乳杆菌以依赖于菌株的方式促进幼年生长，这再现了微生物组对生长和生长激素轴的影响。这些发现表明宿主的微生物组支持幼年生长。此外，我们发现乳杆菌菌株缓冲了慢性营养不足对无菌小鼠出生后生长的不利影响。
