Edmunds Kyle J, Gargiulo Paolo
Institute for Biomedical and Neural Engineering, University of Reykjavík.
Institute for Biomedical and Neural Engineering, University of Reykjavík; University Hospital Landspítali, Reykjavík, Iceland.
Eur J Transl Myol. 2015 Mar 11;25(2):4847. doi: 10.4081/ejtm.2015.4847.
The fields of tissue engineering and regenerative medicine utilize implantable biomaterials and engineered tissues to regenerate damaged cells or replace lost tissues. There are distinct challenges in all facets of this research, but functional assessments and monitoring of such complex environments as muscle tissues present the current strategic priority. Many extant methods for addressing these questions result in the destruction or alteration of tissues or cell populations under investigation. Modern advances in non-invasive imaging modalities present opportunities to rethink some of the anachronistic methods, however, their standard employment may not be optimal when considering advancements in myology. New image analysis protocols and/or combinations of established modalities need to be addressed. This review focuses on efficacies and limitations of available imaging modalities to the functional assessment of implantable myogenic biomaterials and engineered muscle tissues.
组织工程和再生医学领域利用可植入生物材料和工程组织来再生受损细胞或替代缺失组织。这项研究的各个方面都存在独特的挑战，但对肌肉组织等复杂环境进行功能评估和监测是当前的战略重点。许多解决这些问题的现有方法会导致所研究的组织或细胞群体被破坏或改变。然而，非侵入性成像方式的现代进展为重新思考一些过时的方法提供了机会，不过，在考虑肌肉学的进展时，其标准应用可能并非最佳。需要探讨新的图像分析方案和/或现有方式的组合。本综述重点关注现有成像方式在可植入肌源性生物材料和工程肌肉组织功能评估方面的功效和局限性。
