Capron A, Dessaint J P
Centre d'Immunologie et de Biologie Parasitaire Unité Mixte INSERM U167-CNRS 624, Institut Pasteur Lille, France.
Immunol Rev. 1989 Dec;112:27-48. doi: 10.1111/j.1600-065x.1989.tb00551.x.
In spite of some remarkable progress in our understanding of the immune response to parasites and in the molecular cloning of dozens of genes encoding for potentially protective proteins, no definitive step has yet been made towards operational vaccines against major human parasitic diseases. The reasons for our present failures are no longer attributable to the lack of appropriate tools but rather to our rather primitive knowledge of the basic mechanisms governing host-parasite relationship. Mainly on the basics of our personal observations, we have attempted to review and discuss some of the prominent factors in host-parasite interactions, such as molecular mimicry, phyletic convergence, molecular mechanisms of infectivity and lures of cell communication. In many respects, the development of efficient vaccines applicable to humans appears closely dependent on a better understanding of the basic biological mechanisms underlying the natural history of parasitic diseases. In this context, the development of new concepts regarding the definition of potentially protective antigens based on the study of non-surface molecules, cross-reactive stage antigens and antibody isotype selection might represent promising alternatives.
尽管我们在理解对寄生虫的免疫反应以及对数十种编码潜在保护性蛋白质的基因进行分子克隆方面取得了一些显著进展，但在针对主要人类寄生虫病的实用疫苗研发上尚未迈出决定性的一步。我们目前失败的原因不再是缺乏合适的工具，而是源于我们对宿主 - 寄生虫关系基本机制的认识相当原始。主要基于我们个人的观察，我们试图回顾和讨论宿主 - 寄生虫相互作用中的一些突出因素，如分子模拟、系统发育趋同、感染性的分子机制以及细胞通讯的诱因。在许多方面，适用于人类的高效疫苗的研发似乎紧密依赖于对寄生虫病自然史背后基本生物学机制的更好理解。在此背景下，基于对非表面分子、交叉反应阶段抗原和抗体同种型选择的研究来定义潜在保护性抗原的新概念的发展可能是有前景的替代方案。
