Liance M
Laboratoire de Parasitologie, Faculté de Médecine, Créteil, France.
Parasite. 1994 Sep;1(3):197-203. doi: 10.1051/parasite/1994013197.
Although significant advances have been mode during the past 20 years, a better understanding of the orchestration of the immune response against a parasite candidate vaccine is still required for preparing vaccines which can induce the acquisition and the persistence of sterile immunity, without producing side effects in humans. This was, among others, one conclusion of the discussions between Thesis students and scientists. Only some aspects of the different steps of immune responses (recognition, protective effector mechanisms, cell regulation, cytokine activities, immunopathology, parasite escape mechanisms) are here reviewed. They are mainly related to malano and schistosomiasis, but also to other parasitic diseases, for which several experimental models have been developed.
尽管在过去20年中取得了重大进展，但为了制备能够诱导无菌免疫的获得和持续且不会在人体产生副作用的疫苗，仍需要更好地理解针对寄生虫候选疫苗的免疫反应调控机制。这是博士生和科学家之间讨论得出的结论之一。本文仅综述了免疫反应不同步骤（识别、保护性效应机制、细胞调节、细胞因子活性、免疫病理学、寄生虫逃逸机制）的一些方面。这些方面主要与疟疾和血吸虫病有关，但也涉及其他寄生虫病，针对这些疾病已开发了多种实验模型。
