Thorn J J, Prause J U, Oxholm P
Institute of Pathology and Medicine, Royal Dental College, Denmark.
J Oral Pathol Med. 1989 Sep;18(8):457-68. doi: 10.1111/j.1600-0714.1989.tb01343.x.
Sjögren's syndrome (SS) is an autoimmune exocrinopathy. The salivary glands are the site of activated T- and B-lymphocytes, along with gradual parenchymal destruction, diminished flow and altered composition of the secretory product. At present, sialochemistry has achieved no significance for the evaluation of SS patient. However, the number of sialochemical publications is steadily growing. This study review current sialochemical findings in patients with SS and relate the observations to the present concept of diagnosis, pathogenesis and prognosis of SS. An ideal combination of the collection of low-stimulated pure secretion, measurements of absolute flow-rates, and biopsy from the same glands seem to be unobtainable in SS patients. But two procedures may be appropriate: stimulated parotid secretion combined with parotid biopsies, or absorbance of low-stimulated labila saliva combined with labial gland biopsy. Sufficient data on disease-specific alterations in salivary composition in SS are still lacking. However, detection of specific changes in protein synthesis or in glycosylation as well as the detection of inflammatory cell products should be possible with the use of sensitive biochemical assays.
干燥综合征（SS）是一种自身免疫性外分泌腺病。唾液腺是T淋巴细胞和B淋巴细胞激活的部位，同时伴有实质逐渐破坏、分泌减少以及分泌产物成分改变。目前，唾液化学分析对干燥综合征患者的评估尚无意义。然而，唾液化学方面的出版物数量正在稳步增长。本研究回顾了干燥综合征患者目前的唾液化学研究结果，并将这些观察结果与干燥综合征目前的诊断、发病机制和预后概念联系起来。在干燥综合征患者中，似乎无法实现低刺激纯分泌收集、绝对流速测量以及同一腺体活检的理想组合。但有两种方法可能合适：刺激腮腺分泌结合腮腺活检，或低刺激唇腺唾液吸光度结合唇腺活检。关于干燥综合征唾液成分中疾病特异性改变的充分数据仍然缺乏。然而，使用灵敏的生化检测方法应该能够检测到蛋白质合成或糖基化的特定变化以及炎症细胞产物。
