Chen J K, Wang S Y, Hou Y H, Ni G X, Zhang J L, Tang Q G
Lepr Rev. 1989 Dec;60(4):263-6.
Ninety-seven strains of Mycobacterium leprae recovered from patients with previously untreated multibacillary leprosy were tested for dapsone susceptibility. The specimens originated from Shanghai Municipality, Jiang-su Province and Fu-jian Province. Approximately 28% of the strains either did not infect the mice or the results of susceptibility were inconclusive due to the low proportion of viable organisms in the bacterial populations. Among the 70 strains in which dapsone susceptibility could be tested in mice, 31 (44%) strains were found with primary dapsone resistance. Although the majority of the primary dapsone resistant strains were shown to be of a low- or intermediate-degree, one-sixth of them were of high-degree resistance.
对97株从未经治疗的多菌型麻风患者中分离出的麻风分枝杆菌进行了氨苯砜药敏试验。标本来自上海市、江苏省和福建省。约28%的菌株要么未感染小鼠，要么由于细菌群体中活生物体比例低，药敏结果不确定。在70株可在小鼠中进行氨苯砜药敏试验的菌株中，发现31株（44%）菌株对氨苯砜原发耐药。虽然大多数原发氨苯砜耐药菌株表现为低度或中度耐药，但其中六分之一为高度耐药。
