Vaishnavi C, Ganguly N K, Kumar B, Kaur S, Chakravarti R N
Indian J Lepr. 1985 Jul-Sep;57(3):507-13.
20 carefully selected untreated patients of bacilliferous leprosy were investigated for primary dapsone resistance by foot pad inoculation. Mice were fed on 0.001 g% and 0.01 g% of dapsone during the period of study. Mice in the control group were given normal rodent feed only. Animals were sacrificed from 6 month onwards at 6 week intervals upto 9 months. In two animals the growth of M. leprae was not inhibited by 0.001 g% concentration of dapsone in diet, but was completely inhibited by 0.01 g% of dapsone.
对20例精心挑选的未经治疗的带菌麻风患者，通过足垫接种法研究其对氨苯砜的原发性耐药性。在研究期间，给小鼠喂食含0.001%和0.01%氨苯砜的食物。对照组小鼠仅给予正常啮齿动物饲料。从6个月起，每隔6周处死动物，直至9个月。在两只动物中，饮食中0.001%浓度的氨苯砜未抑制麻风杆菌的生长，但0.01%的氨苯砜完全抑制了其生长。
