Senthil Raja, Mohapatra Ranjan Kumar, Sampath Mouleeswaran Koramadai, Sundaraiya Sumati
Department of Nuclear Medicine, Global Hospitals, Chennai, Tamil Nadu, India.
Department of Pathology, Global Hospitals, Chennai, Tamil Nadu, India.
Indian J Nucl Med. 2016 Jan-Mar;31(1):55-8. doi: 10.4103/0972-3919.172364.
Anaplastic large cell lymphoma (ALCL) is a rare type of nonHodgkin's lymphoma (NHL), but one of the most common subtypes of T-cell lymphoma. It is an aggressive T-cell lymphoma, and some ALCL may mimic less aggressive classical HL histopathlogically. It may be misdiagnosed unless careful immunohistochemical examination is performed. As the prognosis and management of these two lymphomas vary significantly, it is important to make a correct diagnosis. We describe a case who was diagnosed as classical HL by histopathological examination of cervical lymph node, in whom (18)F-flouro deoxyglucose positron emission tomography/computed tomography appearances were unusual for HL and warranted review of histopathology that revealed anaplastic lymphoma kinase-1 negative anaplastic large T-cell lymphoma, Hodgkin-like variant, thereby changing the management.
间变性大细胞淋巴瘤(ALCL)是一种罕见的非霍奇金淋巴瘤(NHL),但却是T细胞淋巴瘤最常见的亚型之一。它是一种侵袭性T细胞淋巴瘤,部分ALCL在组织病理学上可能类似侵袭性较低的经典型HL。除非进行仔细的免疫组化检查,否则可能会被误诊。由于这两种淋巴瘤的预后和治疗方法差异很大,因此做出正确诊断很重要。我们描述了一例经颈部淋巴结组织病理学检查诊断为经典型HL的病例,该病例的(18)F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描表现不符合HL的常见表现,因此有必要重新审查组织病理学,结果显示为间变性淋巴瘤激酶-1阴性的间变性大T细胞淋巴瘤,霍奇金样变异型,从而改变了治疗方案。