Ma Xiaojing, Yan Wenjun, Zheng Hua, Du Qinglin, Zhang Lixing, Ban Yi, Li Na, Wei Fang
State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
F1000Res. 2015 Dec 17;4. doi: 10.12688/f1000research.7010.1. eCollection 2015.
Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.
白细胞介素-10和白细胞介素-12主要由病原体激活的抗原呈递细胞产生，尤其是巨噬细胞和树突状细胞。IL-10和IL-12在宿主防御和免疫稳态中发挥着非常重要的免疫调节作用。它们本质上分别具有抗炎和促炎作用，其功能相互拮抗。全面深入地了解它们的免疫学特性和信号传导机制将有助于制定更好的临床干预策略，用于治疗多种人类疾病。在此，我们提供了一些关于IL-10和IL-12免疫信号传导的新出现的概念、争议、未解决的问题及观点的最新情况。
