van Zanten Thomas S, Mayor Satyajit
National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore, 560065, India.
F1000Res. 2015 Nov 30;4. doi: 10.12688/f1000research.6868.1. eCollection 2015.
The local structure and composition of the outer membrane of an animal cell are important factors in the control of many membrane processes and mechanisms. These include signaling, sorting, and exo- and endocytic processes that are occurring all the time in a living cell. Paradoxically, not only are the local structure and composition of the membrane matters of much debate and discussion, the mechanisms that govern its genesis remain highly controversial. Here, we discuss a swathe of new technological advances that may be applied to understand the local structure and composition of the membrane of a living cell from the molecular scale to the scale of the whole membrane.
动物细胞外膜的局部结构和组成是控制许多膜过程和机制的重要因素。这些过程包括信号传导、分选以及活细胞中一直发生的胞吐和胞吞过程。矛盾的是，不仅膜的局部结构和组成是众多争论和讨论的话题，其形成机制也仍然极具争议。在这里，我们讨论一系列新的技术进展，这些进展可用于从分子尺度到整个膜尺度了解活细胞膜的局部结构和组成。
