Tan Hua-Zhen, Lin Wen-Jie, Huang Jin-Qu, Dai Meng, Fu Jian-Hua, Huang Qing-Hua, Chen Wei-Min, Xu Yi-Long, Ye Ting-Ting, Lin Ze-Ying, Lin Xiao-Sheng, Cai Jian-Xiong, Dong Yu-Hao, Luo Hai-Yu, Chen Shuo-Hang, Huang Yong-Lin, Yang Jing, Lin An-Xin, Yuan Xin-Qiang, Chen Sheng-Ying, Wang Kai-Song, Zhuang Cai-Yu, Wang Si-Chao, Lin Li-Ling, Zou Xin-Fei, Song Zhan-Hui, Fang Xiao-Hong, Chen Tong, Zhang Ju-Hong, Li Kai-Qin, Chen Li-Hang, Lin Xiao-Peng, Lin Jing-Mei, Lin Jia-Na, Lin Pei-Le, Chen Jie-Ting, Lin Kai-Miao, Hong Xiao-Chun, Wang Li-Dong, Xu Li-Yan, Li En-Min, Zhang Jian-Jun
The Key Lab of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China.
Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, China.
Dis Esophagus. 2017 Jan 1;30(1):1-7. doi: 10.1111/dote.12468.
Esophageal cancer (EC) is one of the most common cancers in China. The purpose of this study was to investigate the updated incidence rates and risk factors of EC in Nan'ao Island, where the EC incidence rate was chronically the highest in southern China. To calculate the annual incidence rate, data on 338 EC cases from Nan'ao Cancer Registry system diagnosed during 2005-2011 were collected. A case-control study was conducted to explore the EC risk factors. One hundred twenty-five alive EC patients diagnosed during 2005-2011 and 250 controls were enrolled into the case-control study. A pre-test questionnaire on demography, dietary factors, drinking water treatment, and behavioral factors was applied to collect information of all participants. The average EC incidence rates during 2005-2011 were 66.09/105, 94.62/105, 36.83/105 for both genders, males and females, respectively, in Nan'ao Island. The EC incidence rate in males was 2.40- to 4.55-fold higher than that in females in the period from 2006 to 2011 (P < 0.05). Considering the onset age, males tend to be much younger than females and reached peak incidence rate at a younger age (P < 0.05). Drinking water treatment by filter (odds ratio [OR] = 0.28, 95% confidence interval [95% CI] = 0.13-0.58) and fruit consumption (OR = 0.55, 95% CI = 0.32-0.94) reduced the risk for EC. On the contrary, the pickled vegetables consumption (OR = 2.64, 95% CI = 1.46-4.76) and liquor drinking (OR = 2.32, 95% CI = 1.21-4.44) increased the risk for EC. These results may be of importance for future research on EC etiology and prevention strategies.
食管癌（EC）是中国最常见的癌症之一。本研究旨在调查南澳岛食管癌的最新发病率及危险因素，南澳岛长期以来一直是中国南方食管癌发病率最高的地区。为计算年发病率，收集了南澳癌症登记系统2005年至2011年期间诊断出的338例食管癌病例的数据。开展了一项病例对照研究以探索食管癌的危险因素。125例在2005年至2011年期间确诊的存活食管癌患者和250例对照被纳入病例对照研究。采用一份关于人口统计学、饮食因素、饮用水处理及行为因素的预测试问卷来收集所有参与者的信息。2005年至2011年期间，南澳岛男性和女性的食管癌平均发病率分别为66.09/10万、94.62/10万、36.83/10万。2006年至2011年期间，男性食管癌发病率比女性高2.40至4.55倍（P < 0.05）。考虑发病年龄，男性发病年龄往往比女性小得多，且在较年轻的时候达到发病率峰值（P < 0.05）。使用过滤器处理饮用水（比值比[OR] = 0.28，95%置信区间[95%CI] = 0.13 - 0.58）和食用水果（OR = 0.55，95%CI = 0.32 - 0.94）可降低患食管癌的风险。相反，食用腌制蔬菜（OR = 2.64，95%CI = 1.46 - 4.76）和饮用白酒（OR = 2.32，95%CI = 1.21 - 4.44）会增加患食管癌的风险。这些结果可能对未来食管癌病因及预防策略的研究具有重要意义。
