酪氨酸激酶在膀胱癌进展中的作用：概述。
Role of tyrosine kinases in bladder cancer progression: an overview.
机构信息
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Cell Commun Signal. 2020 Aug 14;18(1):127. doi: 10.1186/s12964-020-00625-7.
BACKGROUND
Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases are diagnosed after macroscopic clinical symptoms, it is required to find efficient markers for the early detection. Receptor tyrosine-kinases (RTKs) and non-receptor tyrosine-kinases (nRTKs) have pivotal roles in various cellular processes such as growth, migration, differentiation, and metabolism through different signaling pathways. Tyrosine-kinase deregulations are observed during tumor progressions via mutations, amplification, and chromosomal abnormalities which introduces these factors as important candidates of anti-cancer therapies.
MAIN BODY
For the first time in present review we have summarized all of the reported tyrosine-kinases which have been significantly associated with the clinicopathological features of BCa patients.
CONCLUSIONS
This review highlights the importance of tyrosine-kinases as critical markers in early detection and therapeutic purposes among BCa patients and clarifies the molecular biology of tyrosine-kinases during BCa progression and metastasis. Video abstract.
背景
膀胱癌（BCa）是一种常见的尿路上皮恶性肿瘤，发病率和死亡率都很高。BCa 的发生发展涉及多种遗传和环境因素。由于大多数 BCa 病例在出现明显临床症状后才被诊断出来，因此需要寻找有效的标志物进行早期检测。受体酪氨酸激酶（RTKs）和非受体酪氨酸激酶（nRTKs）通过不同的信号通路在细胞生长、迁移、分化和代谢等多种细胞过程中发挥关键作用。在肿瘤进展过程中，酪氨酸激酶的失调通过突变、扩增和染色体异常等方式发生，这使得这些因素成为癌症治疗的重要候选物。
主要内容
在本次综述中，我们首次总结了所有报道的与 BCa 患者临床病理特征显著相关的酪氨酸激酶。
结论
本综述强调了酪氨酸激酶作为 BCa 患者早期检测和治疗目的的重要标志物的重要性，并阐明了酪氨酸激酶在 BCa 进展和转移过程中的分子生物学。视频摘要。
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