Shin Myung-Seop, Shin Hye-Sun, Ahn Yoo-Been, Kim Hyun-Duck
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
Community Dent Oral Epidemiol. 2016 Aug;44(4):381-9. doi: 10.1111/cdoe.12225. Epub 2016 Feb 26.
This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8-OHdG) and periodontitis among community-dwelling Korean adults.
A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8-OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8-OHdG.
The high 8-OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8-OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028).
8-OHdG was associated with periodontitis. Thus, salivary 8-OHdG could be a useful marker for periodontitis.
本研究旨在评估韩国社区居住成年人唾液中8-羟基脱氧鸟苷（8-OHdG）与牙周炎之间的关联。
从淳昌长寿队列中对211名成年人（80名男性和131名女性）进行了横断面调查。牙周炎定义为至少30%的牙齿近中附着丧失≥5mm。唾液8-OHdG水平分为三分位数：低（<0.916 ng/ml）、中（0.916至<2.675 ng/ml）和高（≥2.675 ng/ml）。对社会人口统计学、习惯和全身健康相关因素进行了控制。对重度牙周炎的结果进行了逻辑回归分析。对8-OHdG的结果进行了一般线性模型中的协方差分析。
高8-OHdG水平与牙周炎呈显著关联。优势比（95%置信区间）为2.40（1.05-5.51），通过添加与饮酒和吸烟的交互项得到了突出显示。重度牙周炎组8-OHdG的调整后平均对数转换值（1.40 ng/ml）显著高于对照组（1.02 ng/ml）（协方差分析，P = 0.028）。
8-OHdG与牙周炎有关。因此，唾液8-OHdG可能是牙周炎的一个有用标志物。
