Sugano Naoyuki, Yokoyama Kyosuke, Oshikawa Maiko, Kumagai Kyoichi, Takane Masatoshi, Tanaka Hajime, Ito Koichi
Department of Periodontology, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
J Oral Sci. 2003 Dec;45(4):181-4. doi: 10.2334/josnusd.45.181.
Several studies have demonstrated a close association between Streptococcus (S.) anginosus infection and head and neck cancer. Accumulation of 8-hydroxy-deoxyguanosine (8-OHdG), which may result from the continuous generation of reactive oxygen species associated with chronic inflammation, has been reported in human preneoplastic lesions and in cancerous tissues. The purpose of the present investigation was to assess the salivary levels of S. anginosus and 8-OHdG in patients with periodontitis. Salivary levels of S. anginosus were measured by real-time PCR. S. anginosus was detected in 28 out of 38 (73.7%) of subjects. The 8-OHdG level was significantly higher in patients positive for S. anginosus than in patients negative for the bacterium. A significant decrease in S. anginosus and 8-OHdG levels was observed after initial periodontal treatment. Our findings indicate that, although the levels of S. anginosus are relatively low, there is a correlation between the salivary level of S. anginosus and 8-OHdG, and that periodontal treatment can decrease the levels of these hazard factors.
多项研究表明，咽峡炎链球菌感染与头颈癌之间存在密切关联。在人类癌前病变和癌组织中已报告有8-羟基脱氧鸟苷（8-OHdG）的积累，这可能是由与慢性炎症相关的活性氧持续产生所致。本研究的目的是评估牙周炎患者唾液中咽峡炎链球菌和8-OHdG的水平。通过实时聚合酶链反应测量咽峡炎链球菌的唾液水平。在38名受试者中的28名（73.7%）检测到咽峡炎链球菌。咽峡炎链球菌呈阳性的患者的8-OHdG水平显著高于该细菌呈阴性的患者。在初始牙周治疗后，观察到咽峡炎链球菌和8-OHdG水平显著下降。我们的研究结果表明，尽管咽峡炎链球菌的水平相对较低，但咽峡炎链球菌的唾液水平与8-OHdG之间存在相关性，并且牙周治疗可以降低这些危险因素的水平。
