Martu Maria-Alexandra, Surlin Petra, Lazar Luminita, Maftei George Alexandru, Luchian Ionut, Gheorghe Dorin-Nicolae, Rezus Elena, Toma Vasilica, Foia Liliana-Georgeta
"Grigore T. Popa", University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania.
Department of Periodontology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Str., 200349 Craiova, Romania.
Antioxidants (Basel). 2021 Feb 3;10(2):226. doi: 10.3390/antiox10020226.
(1) Background: The aim of this split-mouth design study was to analyze the clinical periodontal indexes and oxidative stress markers in gingival crevicular fluid modifications after three periodontal disease treatment possibilities (scaling and root planning-SRP; SRP and diode laser-L; SRP and photodynamic therapy-PDT). (2) Methods: The study was conducted on 52 patients: systemically healthy subjects with periodontal disease-non-RA ( = 26); and test group ( = 26) subjects with rheumatoid arthritis and periodontal disease-RA. Clinical periodontal measurements (probing depth-PD; Löe and Silness gingival index-GI; papillary bleeding index-PBI; and periodontal community index of treatment needs-CPITN) and oxidative stress markers (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4 hydroxynonenal (4-HNE)) were analyzed at baseline (T0), after three sessions of periodontal treatment (T1), and 6 months after treatment (T2). (3) Results: Periodontal therapy improved clinical periodontal measurements and oxidative stress markers in both analyzed groups, with supplementary benefits for laser- and PDT-treated periodontal pockets. (4) Conclusions: The analyzed oxidative stress markers decreased significantly following non-surgical periodontal therapy in both rheumatoid arthritis and systemically healthy patients. All the periodontal disease treatment possibilities analyzed in this study offered clinical and paraclinical improvements; however, the association of laser with SRP and photodisinfection with SRP yielded the best clinical and paraclinical outcomes when compared to SRP alone.
(1) 背景：本双盲设计研究的目的是分析三种牙周疾病治疗方法（龈下刮治术和根面平整术 - SRP；SRP 与二极管激光 - L；SRP 与光动力疗法 - PDT）后龈沟液改变中的临床牙周指标和氧化应激标志物。(2) 方法：对 52 名患者进行了研究：患有牙周疾病的全身健康受试者 - 非类风湿性关节炎（n = 26）；以及试验组（n = 26）患有类风湿性关节炎和牙周疾病的受试者 - 类风湿性关节炎。在基线（T0）、三次牙周治疗后（T1）以及治疗后 6 个月（T2）分析临床牙周测量指标（探诊深度 - PD；洛和西勒斯牙龈指数 - GI；龈乳头出血指数 - PBI；以及治疗需要的牙周社区指数 - CPITN）和氧化应激标志物（8 - 羟基 - 2'-脱氧鸟苷（8 - OHdG）和 4 - 羟基壬烯醛（4 - HNE））。(3) 结果：牙周治疗改善了两个分析组的临床牙周测量指标和氧化应激标志物，对激光和 PDT 治疗的牙周袋有额外益处。(4) 结论：在类风湿性关节炎患者和全身健康患者中，非手术牙周治疗后分析的氧化应激标志物均显著降低。本研究分析的所有牙周疾病治疗方法均带来了临床和临床旁改善；然而，与单独的 SRP 相比，激光与 SRP 的联合以及光消毒与 SRP 的联合产生了最佳的临床和临床旁结果。
