Heath D, Khan Q, Nash J, Smith P
Department of Pathology, University of Liverpool.
Postgrad Med J. 1989 Jun;65(764):353-7. doi: 10.1136/pgmj.65.764.353.
There are three types of histological change in the carotid bodies which appear to have physiological and clinical associations. A prominence of the dark variant of chief cells with their contents of met-enkephalin and other peptides appears to be associated with acute exposure to hypoxia. Proliferation of sustentacular cells around the clusters of chief cells appears to be related to ageing and also to systemic hypertension. Recently we have described a new condition of chronic carotid glomitis which is characterized by follicles of lymphocytes and may have a basis in auto-immunity. In the present review we report for the first time plasma cell activity in the carotid bodies of an elderly man, especially around nerve fibrils and unmyelinated axons ensheathed in sustentacular cells. Such appearances are consistent with the view that ageing nerve fibrils may be the antigenic stimulus for the development of chronic carotid glomitis.
颈动脉体存在三种组织学变化，它们似乎具有生理和临床关联。主细胞深色变体及其脑啡肽和其他肽类物质含量的增多似乎与急性低氧暴露有关。主细胞簇周围支持细胞的增殖似乎与衰老以及系统性高血压有关。最近我们描述了一种慢性颈动脉球炎的新情况，其特征为淋巴细胞滤泡，可能有自身免疫基础。在本综述中，我们首次报告了一名老年男性颈动脉体中的浆细胞活性，尤其是在支持细胞包裹的神经纤维和无髓轴突周围。这些表现与衰老神经纤维可能是慢性颈动脉球炎发生的抗原刺激这一观点一致。
