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[阻塞性睡眠呼吸暂停患者鼻腔持续气道正压通气治疗前后咽部的视频内镜记录]

[Video-endoscopic recording of the pharynx before and following nasal continuous positive airway pressure therapy in patients with obstructive sleep apnea].

作者信息

Becker H, Peter J H, von Wichert P

出版信息

Pneumologie. 1989 Nov;43 Suppl 1:616-20.

PMID:2692021
Abstract

The action mechanism of nCPAP in the treatment of obstructive sleep apnea is not adequately known. We took video endoscopic pictures (chip video camera manufactured by Videotronik) of the pharynx in five patients with SA in the awake state, during apnea during sleep, and under nCPAP treatment during sleep. The patients were all in the supine position. Simultaneously with video-endoscopy, polysomnography was performed. Qualitatively good pictures were obtained in 3 patients. In the awake state, a relatively narrow pharynx was observed which, however, was completely patent during the entire respiratory cycle. During apnea and hypopnoea, a concentric collapse of the oropharynx was observed, with involvement of the lateral and posterior walls of the pharynx and the tongue, together with the soft palate over a length of several centimetres to above the epiglottis. During the hyperventilation phase following apnea, the occlusion opened up again, the diameter of the pharynx then being appreciably greater than that seen in the awake state. Under increasing CPAP pressure, occlusion became progressively less complete; when the effective pressure had been attained, the diameter of the pharynx was roughly comparable to that seen in the hyperventilation phase, that is, appreciably wider than in the awake state. During inspiration, however, even under effective nCPAP pressure, a discrete decrease in pharyngeal diameter occurred. On the basis of the visual impression, we believe that the effect of CPAP is based on a passive "pneumatic splinting" of the pharyngeal musculature.

摘要

无创持续气道正压通气(nCPAP)治疗阻塞性睡眠呼吸暂停的作用机制尚不完全清楚。我们用视频内窥镜(由Videotronik制造的芯片摄像机)拍摄了5例睡眠呼吸暂停(SA)患者在清醒状态、睡眠呼吸暂停期间以及睡眠时nCPAP治疗下的咽部图像。患者均取仰卧位。在进行视频内窥镜检查的同时,进行了多导睡眠图监测。3例患者获得了质量较好的图像。在清醒状态下,观察到咽部相对狭窄,但在整个呼吸周期中完全通畅。在呼吸暂停和呼吸浅慢期间,观察到口咽呈同心性塌陷,咽侧壁、后壁、舌以及软腭在数厘米长度直至会厌上方均受累。在呼吸暂停后的过度通气阶段,阻塞再次打开,此时咽部直径明显大于清醒状态下所见。随着CPAP压力增加,阻塞逐渐变得不那么完全;当达到有效压力时,咽部直径大致与过度通气阶段所见相当,即明显宽于清醒状态。然而,在吸气时,即使在有效的nCPAP压力下,咽部直径也会出现离散性减小。基于视觉印象,我们认为CPAP的作用基于咽部肌肉组织的被动“气动夹板”作用。

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