Kapoor Neena, Raj Revathi
Blood and Marrow Transplantation Program, Childrens Hospital, Los Angeles, 4650 Sunset Blvd., Los Angeles, CA, 90027, USA.
Department of Blood and Marrow Transplantation, Apollo Speciality Hospital, 320 Padma Complex, Anna Salai, Chennai, 600035, India.
Indian J Pediatr. 2016 May;83(5):450-4. doi: 10.1007/s12098-015-2012-z. Epub 2016 Feb 27.
Hematopoietic stem cell transplantation provides a curative option for children with primary immune deficiency disorders. Increased awareness and rapid diagnosis of these conditions has resulted in early referral and the chance to offer a curative option for affected children. Management of these children involves a multidisciplinary team including infectious disease specialists and intensivists. The use of reduced intensity conditioning chemotherapy, advances in detection and therapy of viral and fungal infections, optimal supportive care and techniques in stem cell processing, including T cell depletion has enabled doctors to transplant children with co-morbid conditions and no matched donors. Transplantation for these children has also brought in deep insights into the world of immunology and infectious diseases.
造血干细胞移植为患有原发性免疫缺陷疾病的儿童提供了一种治愈性选择。对这些病症的认识提高和快速诊断，使得患儿能够尽早转诊，并获得为患病儿童提供治愈性选择的机会。对这些儿童的管理需要一个多学科团队，包括传染病专家和重症监护医生。降低强度预处理化疗的应用、病毒和真菌感染检测与治疗方面的进展、最佳支持治疗以及干细胞处理技术（包括T细胞清除），使医生能够为患有合并症且没有匹配供体的儿童进行移植。对这些儿童的移植也为免疫学和传染病领域带来了深刻见解。
