与2型糖尿病相关的基因rs10830963 C/G多态性：对13752名参与者的最新荟萃分析

gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants.

作者信息

Li Yan-Yan, Wang Hui, Zhang Yang-Yang

机构信息

Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, China.

Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, China.

出版信息

Heliyon. 2022 Nov 21;8(11):e11786. doi: 10.1016/j.heliyon.2022.e11786. eCollection 2022 Nov.

BACKGROUND AND AIMS

It has been indicated that gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reached now. Hence, the present meta-analysis was conducted to illuminate the potential association of human gene rs10830963 C/G polymorphism and T2DM.

METHODS AND RESULTS

There were 13,752 participants from 7 studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed by using the fixed or random effects models. A significant association between gene rs10830963 C/G polymorphism and T2DM was found under recessive (OR: 1.148, 95% CI: 1.052-1.253, P = 0.002), homozygous (OR: 1.197, 95% CI: 1.023-1.401, P = 0.025), and additive (OR: 1.067, 95% CI: 1.017-1.120, P = 0.008) genetic models.

CONCLUSIONS

gene rs10830963 C/G polymorphism was significantly related to T2DM in the Chinese population. The persons with G allele of the gene rs10830963 C/G polymorphism might be the T2DM susceptible population.

背景与目的

已有研究表明基因rs10830963 C/G多态性与2型糖尿病（T2DM）风险增加有关。然而，由于关于该主题的个体研究结果不一致，目前尚未达成共识。因此，进行本荟萃分析以阐明人类基因rs10830963 C/G多态性与T2DM之间的潜在关联。

方法与结果

本荟萃分析纳入了7项研究中的13752名参与者。采用固定效应模型或随机效应模型评估合并比值比（OR）及其相应的95%置信区间（CI）。在隐性遗传模型（OR：1.148，95%CI：1.052 - 1.253，P = 0.002）、纯合子遗传模型（OR：1.197，95%CI：1.023 - 1.401，P = 0.025）和显性遗传模型（OR：1.067，95%CI：1.017 - 1.120，P = 0.008）中发现基因rs10830963 C/G多态性与T2DM之间存在显著关联。