Liu Yi-Ying, Wan Qin
Department of Endocrinology, Deyang People's Hospital, Deyang 618000, Sichuan Province, China.
Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
World J Diabetes. 2023 Dec 15;14(12):1803-1812. doi: 10.4239/wjd.v14.i12.1803.
Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with genetic and environmental factors.
To explore the relationship between the glucokinase regulatory protein () gene rs780094 polymorphism and T2D with albuminuria.
We selected 252 patients (126 males and 126 females) with T2D admitted to our hospital from January 2020 to October 2020, and 66 healthy people (44 females and 22 males). According to the urinary albumin/creatinine ratio, the subjects were divided into group I (control), group II (T2D with normoalbuminuria), group III (T2D with microalbuminuria), and group IV (T2D with macroalbuminuria). Additionly, the subjects were divided into group M (normal group) or group N (albuminuria group) according to whether they developed albuminuria. We detected the gene rs780094 polymorphism (C/T) of all subjects, and measured the correlation between gene rs780094 polymorphism (C/T) and T2D with albuminuria.
Gene distribution and genotype distribution among groups I-IV accorded with the Hardy-Weinberg equilibrium. Genotype frequency was significantly different among the four groups ( = 0.048, = 7.906). T allele frequency in groups II, III, and IV was significantly higher than that in group I. Logistic regression analysis of the risk factors for T2D with albuminuria showed that the CT + TT genotype (odds ratio = 1.710, 95% confidence interval: 1.172-2.493) was a risk factor.
CT + TT genotype is a risk factor for T2D with albuminuria. In the future, we can assess the risk of individuals carrying susceptible genes to delay the onset of T2D.
糖尿病肾病是2型糖尿病（T2D）常见的并发症之一。早期无典型症状，当蛋白尿达到高水平时疾病会进展至中晚期。治疗困难且预后较差。目前，糖尿病肾病的发病机制仍不清楚，人们认为其与遗传和环境因素有关。
探讨葡萄糖激酶调节蛋白（）基因rs780094多态性与T2D伴蛋白尿之间的关系。
选取2020年1月至2020年10月我院收治的252例T2D患者（男126例，女126例）以及66例健康人（女44例，男22例）。根据尿白蛋白/肌酐比值，将受试者分为I组（对照组）、II组（T2D伴正常白蛋白尿）、III组（T2D伴微量白蛋白尿）和IV组（T2D伴大量白蛋白尿）。此外，根据是否发生白蛋白尿将受试者分为M组（正常组）或N组（白蛋白尿组）。检测所有受试者的基因rs780094多态性（C/T），并测定基因rs780094多态性（C/T）与T2D伴蛋白尿之间的相关性。
I - IV组间基因分布和基因型分布符合Hardy-Weinberg平衡。四组间基因型频率差异有统计学意义（ = 0.048， = 7.906）。II、III和IV组的T等位基因频率显著高于I组。对T2D伴蛋白尿的危险因素进行Logistic回归分析显示，CT + TT基因型（比值比 = 1.710，95%置信区间：1.172 - 2.493）是危险因素。
CT + TT基因型是T2D伴蛋白尿的危险因素。未来，我们可以评估携带易感基因个体的风险以延缓T2D的发病。
